An infusion of the wood and bark of Erythroxylum monogynum is stomachic, diaphoretic and stimulant diuretic. It is useful in some slight cases of dyspepsia and continued fever. (Dr. Moodeen Sheriff in Basu & Kirtikar, Indian Medicinal Plants)

The leaves contain an alkaloid, which is bitter and astringent (Trimen H.; continued by Hooker J.D.) but it has none of the properties of cocaine, the alkaloid obtained from Erythroxylum Coca of South America.
The aromatic leaves are stomachic, diuretic, diaphoretic. They are used for stomach upsets and fever. The leaf juice is given to treat jaundice, malaria and to kill intestinal worms. A paste made from the leaves is applied to wounds. (Quattrocchi, CRC World Dictionary of Medicinal and Poisonous Plants)

The stem and the roots ashes and oil substance of the plant are applied to skin diseases and scabies. (Quattrocchi, CRC World Dictionary of Medicinal and Poisonous Plants).

The oil from the seed is known to cure psoriasis.